Drug interactions
Clomipramine + Guanfacine
Severity: Moderate
Clomipramine and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may blunt the antihypertensive effect of centrally acting alpha-2 agonists like guanfacine. Blood pressure control may be lost, and additive sedation is possible.
What this interaction means in plain words
Clomipramine and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.
Why it happens
Probable pharmacodynamic antagonism through tricyclic effects on adrenergic neurons and alpha-2 mediated actions.
What to do
Monitor blood pressure after starting or changing clomipramine and adjust guanfacine or consider another antihypertensive class if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Clomipramine with Guanfacine?
MediHelp rates the interaction as moderate. Clomipramine and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may blunt the antihypertensive effect of centrally acting alpha-2 agonists like guanfacine. Blood pressure control may be lost, and additive sedation is possible.
How serious is the interaction between Clomipramine and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or changing clomipramine and adjust guanfacine or consider another antihypertensive class if control is lost.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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