Drug interactions
Clomipramine + Hydrocodone
Severity: Moderate
Clomipramine and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is strongly serotonergic and, with an opioid, may cause serotonin syndrome. Additive CNS depression is also possible, and clomipramine inhibits CYP2D6 modestly.
What this interaction means in plain words
Clomipramine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive serotonergic effects and additive CNS depression, with possible CYP2D6 inhibition by clomipramine.
What to do
Monitor for serotonin toxicity and excessive sedation, especially when starting or increasing doses. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Hydrocodone?
MediHelp rates the interaction as moderate. Clomipramine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is strongly serotonergic and, with an opioid, may cause serotonin syndrome. Additive CNS depression is also possible, and clomipramine inhibits CYP2D6 modestly.
How serious is the interaction between Clomipramine and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and excessive sedation, especially when starting or increasing doses. Use the lowest effective doses.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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