Drug interactions
Clomipramine + Imatinib
Severity: Moderate
Clomipramine and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and CYP3A4 and may raise clomipramine and desmethylclomipramine concentrations. This can increase anticholinergic effects, sedation, seizure risk and cardiac conduction effects. Imatinib itself can occasionally prolong the QT interval.
What this interaction means in plain words
Clomipramine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP2D6 (and CYP3A4) mediated metabolism of clomipramine.
What to do
Monitor for tricyclic toxicity and consider a lower clomipramine dose or serum level monitoring. Obtain an ECG if symptoms or other QT risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Clomipramine with Imatinib?
MediHelp rates the interaction as moderate. Clomipramine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and CYP3A4 and may raise clomipramine and desmethylclomipramine concentrations. This can increase anticholinergic effects, sedation, seizure risk and cardiac conduction effects. Imatinib itself can occasionally prolong the QT interval.
How serious is the interaction between Clomipramine and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider a lower clomipramine dose or serum level monitoring. Obtain an ECG if symptoms or other QT risks are present.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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