Drug interactions
Clomipramine + Indomethacin
Severity: Moderate
Clomipramine and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a potent serotonin reuptake inhibitor and, combined with indomethacin, increases the risk of upper gastrointestinal bleeding. The effect is additive on both platelet function and mucosal injury.
What this interaction means in plain words
Clomipramine and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Indomethacin belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin from reuptake inhibition impairs aggregation, adding to NSAID-induced COX-1 inhibition and mucosal damage.
What to do
Use an alternative analgesic where possible, or give a proton pump inhibitor with the combination. Monitor for signs of GI bleeding and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Indomethacin?
MediHelp rates the interaction as moderate. Clomipramine and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a potent serotonin reuptake inhibitor and, combined with indomethacin, increases the risk of upper gastrointestinal bleeding. The effect is additive on both platelet function and mucosal injury.
How serious is the interaction between Clomipramine and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative analgesic where possible, or give a proton pump inhibitor with the combination. Monitor for signs of GI bleeding and anemia.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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