Drug interactions
Clomipramine + Isoproterenol
Severity: Moderate
Clomipramine and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can alter the response to sympathomimetic amines, and this may enhance cardiovascular effects such as tachycardia, hypertension or arrhythmia. The effect is less pronounced with isoproterenol, a direct beta agonist not dependent on reuptake, but cardiac sensitivity may still be increased.
What this interaction means in plain words
Clomipramine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Tricyclic blockade of norepinephrine reuptake and increased adrenergic sensitivity, with additive arrhythmogenic potential.
What to do
Monitor heart rate, blood pressure and ECG when isoproterenol is given to a patient on clomipramine, and titrate the isoproterenol dose cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Clomipramine with Isoproterenol?
MediHelp rates the interaction as moderate. Clomipramine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can alter the response to sympathomimetic amines, and this may enhance cardiovascular effects such as tachycardia, hypertension or arrhythmia. The effect is less pronounced with isoproterenol, a direct beta agonist not dependent on reuptake, but cardiac sensitivity may still be increased.
How serious is the interaction between Clomipramine and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when isoproterenol is given to a patient on clomipramine, and titrate the isoproterenol dose cautiously.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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