Drug interactions
Clomipramine + Ketoprofen
Severity: Moderate
Clomipramine and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a strongly serotonergic tricyclic and, like SSRIs, may increase bleeding risk when combined with NSAIDs, particularly in the upper gastrointestinal tract.
What this interaction means in plain words
Clomipramine and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Ketoprofen belongs to Musculoskeletal.
Why it happens
Inhibition of platelet serotonin uptake impairs platelet aggregation, adding to NSAID antiplatelet effects and mucosal injury.
What to do
Monitor for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Limit ketoprofen dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Ketoprofen?
MediHelp rates the interaction as moderate. Clomipramine and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a strongly serotonergic tricyclic and, like SSRIs, may increase bleeding risk when combined with NSAIDs, particularly in the upper gastrointestinal tract.
How serious is the interaction between Clomipramine and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Limit ketoprofen dose and duration.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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