Drug interactions
Clomipramine + Leniolisib
Severity: Moderate
Clomipramine and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib may raise exposure to CYP1A2 substrates, and clomipramine is partly metabolized by CYP1A2. Higher clomipramine levels could increase anticholinergic effects, seizure risk, sedation and cardiac conduction effects.
What this interaction means in plain words
Clomipramine and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib weakly inhibits CYP1A2, reducing the metabolism of clomipramine (partly a CYP1A2 substrate).
What to do
Monitor for tricyclic adverse effects such as sedation, anticholinergic effects and ECG changes, and consider reducing the clomipramine dose. If toxicity appears, check clomipramine concentrations where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Clomipramine with Leniolisib?
MediHelp rates the interaction as moderate. Clomipramine and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib may raise exposure to CYP1A2 substrates, and clomipramine is partly metabolized by CYP1A2. Higher clomipramine levels could increase anticholinergic effects, seizure risk, sedation and cardiac conduction effects.
How serious is the interaction between Clomipramine and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects such as sedation, anticholinergic effects and ECG changes, and consider reducing the clomipramine dose. If toxicity appears, check clomipramine concentrations where available.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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