Drug interactions
Clomipramine + Levetiracetam
Severity: Moderate
Clomipramine and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, dizziness and fatigue, so combined use may increase sedation and impair driving. Clomipramine also lowers the seizure threshold, which may work against the antiseizure effect of levetiracetam.
What this interaction means in plain words
Clomipramine and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depression; the tricyclic also lowers seizure threshold, a pharmacodynamic opposition.
What to do
Counsel patients about sedation and driving, and monitor seizure control after starting or increasing clomipramine. Use the lowest effective clomipramine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Clomipramine with Levetiracetam?
MediHelp rates the interaction as moderate. Clomipramine and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, dizziness and fatigue, so combined use may increase sedation and impair driving. Clomipramine also lowers the seizure threshold, which may work against the antiseizure effect of levetiracetam.
How serious is the interaction between Clomipramine and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation and driving, and monitor seizure control after starting or increasing clomipramine. Use the lowest effective clomipramine dose.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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