Drug interactions
Clomipramine + Loxapine
Severity: Moderate
Clomipramine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and anticholinergic effects, and loxapine may raise tricyclic levels through CYP2D6 competition. Clomipramine and loxapine both lower the seizure threshold, so seizure risk may rise.
What this interaction means in plain words
Clomipramine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, anticholinergic effects and seizure threshold lowering; possible CYP2D6 competition.
What to do
Monitor for sedation, anticholinergic effects and seizures, and consider dose reduction of clomipramine if toxicity appears. Counsel patients on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Clomipramine with Loxapine?
MediHelp rates the interaction as moderate. Clomipramine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and anticholinergic effects, and loxapine may raise tricyclic levels through CYP2D6 competition. Clomipramine and loxapine both lower the seizure threshold, so seizure risk may rise.
How serious is the interaction between Clomipramine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and seizures, and consider dose reduction of clomipramine if toxicity appears. Counsel patients on driving and alcohol.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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