Drug interactions
Clomipramine + Memantine-donepezil
Severity: Moderate
Clomipramine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has anticholinergic activity that can oppose the effect of donepezil and worsen cognition in dementia. Both drugs may also prolong the QT interval, adding to arrhythmia risk.
What this interaction means in plain words
Clomipramine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between anticholinergic and cholinesterase inhibitor effects, plus additive QTc prolongation.
What to do
Prefer an antidepressant with less anticholinergic activity, such as an SSRI with low QT liability. If used together, monitor cognition and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Clomipramine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has anticholinergic activity that can oppose the effect of donepezil and worsen cognition in dementia. Both drugs may also prolong the QT interval, adding to arrhythmia risk.
How serious is the interaction between Clomipramine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antidepressant with less anticholinergic activity, such as an SSRI with low QT liability. If used together, monitor cognition and ECG.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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