Drug interactions
Clomipramine + Methocarbamol
Severity: Moderate
Clomipramine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a sedating tricyclic antidepressant with anticholinergic effects. Together with methocarbamol it can deepen sedation and impair concentration and psychomotor function, particularly in older adults.
What this interaction means in plain words
Clomipramine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of a tricyclic antidepressant and a centrally acting muscle relaxant.
What to do
Monitor for excessive drowsiness, confusion and falls, especially at initiation or dose increases. Reduce the dose of one agent if sedation becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Methocarbamol?
MediHelp rates the interaction as moderate. Clomipramine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a sedating tricyclic antidepressant with anticholinergic effects. Together with methocarbamol it can deepen sedation and impair concentration and psychomotor function, particularly in older adults.
How serious is the interaction between Clomipramine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, confusion and falls, especially at initiation or dose increases. Reduce the dose of one agent if sedation becomes problematic.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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