Drug interactions
Clomipramine + Naratriptan
Severity: Moderate
Clomipramine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine strongly inhibits serotonin reuptake and triptans act on serotonin receptors, so combined use could theoretically precipitate serotonin syndrome. Reported cases with tricyclics are rare, but symptoms such as agitation, tremor, hyperthermia and clonus can be serious.
What this interaction means in plain words
Clomipramine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from serotonin reuptake inhibition plus 5-HT1B/1D agonism.
What to do
Counsel the patient to report agitation, tremor, sweating, diarrhea or fever after a triptan dose. Stop the triptan and treat if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Clomipramine with Naratriptan?
MediHelp rates the interaction as moderate. Clomipramine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine strongly inhibits serotonin reuptake and triptans act on serotonin receptors, so combined use could theoretically precipitate serotonin syndrome. Reported cases with tricyclics are rare, but symptoms such as agitation, tremor, hyperthermia and clonus can be serious.
How serious is the interaction between Clomipramine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating, diarrhea or fever after a triptan dose. Stop the triptan and treat if serotonin toxicity is suspected.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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