Drug interactions
Clomipramine + Oliceridine
Severity: Major
Clomipramine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine can raise oliceridine exposure by inhibiting CYP2D6, and both drugs add to CNS depression. Serotonergic effects are also possible, so respiratory depression, sedation and rarely serotonin syndrome are concerns.
What this interaction means in plain words
Clomipramine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2D6 metabolism of oliceridine plus additive CNS depressant and serotonergic effects.
What to do
If coadministration is needed, give lower or less frequent oliceridine doses and monitor for respiratory depression, sedation and serotonin toxicity. Re-titrate the opioid if clomipramine is started or stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Clomipramine with Oliceridine?
MediHelp rates the interaction as major. Clomipramine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clomipramine can raise oliceridine exposure by inhibiting CYP2D6, and both drugs add to CNS depression. Serotonergic effects are also possible, so respiratory depression, sedation and rarely serotonin syndrome are concerns.
How serious is the interaction between Clomipramine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, give lower or less frequent oliceridine doses and monitor for respiratory depression, sedation and serotonin toxicity. Re-titrate the opioid if clomipramine is started or stopped.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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