Drug interactions
Clomipramine + Orphenadrin
Severity: Moderate
Clomipramine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a tricyclic with strong anticholinergic and sedative properties, and orphenadrine adds to both. The combination can cause marked sedation, confusion, urinary retention, constipation, tachycardia and in severe cases delirium.
What this interaction means in plain words
Clomipramine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive muscarinic receptor blockade and central sedative effects.
What to do
Monitor for anticholinergic toxicity and oversedation, and reduce doses if they develop. Avoid in elderly patients or those with glaucoma, urinary retention or cognitive impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Orphenadrin?
MediHelp rates the interaction as moderate. Clomipramine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a tricyclic with strong anticholinergic and sedative properties, and orphenadrine adds to both. The combination can cause marked sedation, confusion, urinary retention, constipation, tachycardia and in severe cases delirium.
How serious is the interaction between Clomipramine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and oversedation, and reduce doses if they develop. Avoid in elderly patients or those with glaucoma, urinary retention or cognitive impairment.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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