Drug interactions
Clomipramine + Oxaprozin
Severity: Moderate
Clomipramine and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a strongly serotonergic tricyclic and, like SSRIs, may increase the risk of gastrointestinal bleeding when combined with NSAIDs. The risk is higher in older patients and those with ulcer history.
What this interaction means in plain words
Clomipramine and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Oxaprozin belongs to Musculoskeletal.
Why it happens
Inhibition of platelet serotonin uptake impairs platelet aggregation, adding to NSAID antiplatelet and mucosal-damaging effects.
What to do
Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for GI bleeding. Prefer a non-NSAID analgesic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Oxaprozin?
MediHelp rates the interaction as moderate. Clomipramine and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a strongly serotonergic tricyclic and, like SSRIs, may increase the risk of gastrointestinal bleeding when combined with NSAIDs. The risk is higher in older patients and those with ulcer history.
How serious is the interaction between Clomipramine and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for GI bleeding. Prefer a non-NSAID analgesic if possible.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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