Drug interactions
Clomipramine + Rifapentine
Severity: Moderate
Clomipramine and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is a CYP3A4 inducer and may lower clomipramine exposure, potentially reducing therapeutic effect. The induction is somewhat weaker than that of rifampin but is still relevant over a prolonged course.
What this interaction means in plain words
Clomipramine and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 (and related enzymes) by rifapentine increasing clomipramine metabolism.
What to do
Monitor the antidepressant response and adjust the clomipramine dose, using plasma concentrations if available. Reassess the dose when rifapentine ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Clomipramine with Rifapentine?
MediHelp rates the interaction as moderate. Clomipramine and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is a CYP3A4 inducer and may lower clomipramine exposure, potentially reducing therapeutic effect. The induction is somewhat weaker than that of rifampin but is still relevant over a prolonged course.
How serious is the interaction between Clomipramine and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the antidepressant response and adjust the clomipramine dose, using plasma concentrations if available. Reassess the dose when rifapentine ends.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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