Drug interactions
Clomipramine + Sitagliptin
Severity: Minor
Clomipramine and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may alter glycemic control, so a slight additive glucose-lowering effect with sitagliptin is theoretically possible. The practical impact is probably minimal given the low hypoglycemia potential of sitagliptin.
What this interaction means in plain words
Clomipramine and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Sitagliptin belongs to Endocrine.
Why it happens
Theoretical additive pharmacodynamic effect on glucose homeostasis; not well established.
What to do
No specific action is required; monitor glucose when clomipramine is started or stopped and adjust diabetes treatment only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Clomipramine with Sitagliptin?
MediHelp rates the interaction as minor. Clomipramine and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may alter glycemic control, so a slight additive glucose-lowering effect with sitagliptin is theoretically possible. The practical impact is probably minimal given the low hypoglycemia potential of sitagliptin.
How serious is the interaction between Clomipramine and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor glucose when clomipramine is started or stopped and adjust diabetes treatment only if control changes.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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