Drug interactions
Clomipramine + Sparsentan
Severity: Moderate
Clomipramine and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan can induce CYP2C19, which contributes to clomipramine demethylation. Clomipramine exposure may fall, with a possible loss of effect, though the overall impact on the active metabolite balance is uncertain.
What this interaction means in plain words
Clomipramine and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
CYP2C19 induction by sparsentan increases clomipramine metabolism.
What to do
Monitor antidepressant or antiobsessional response after starting sparsentan and increase the clomipramine dose if efficacy declines. Consider plasma level monitoring where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Clomipramine with Sparsentan?
MediHelp rates the interaction as moderate. Clomipramine and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan can induce CYP2C19, which contributes to clomipramine demethylation. Clomipramine exposure may fall, with a possible loss of effect, though the overall impact on the active metabolite balance is uncertain.
How serious is the interaction between Clomipramine and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant or antiobsessional response after starting sparsentan and increase the clomipramine dose if efficacy declines. Consider plasma level monitoring where available.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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