Drug interactions
Clomipramine + Sulindac
Severity: Moderate
Clomipramine and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine, a potent serotonin reuptake inhibitor, can increase bleeding tendency when combined with an NSAID, particularly in the upper gastrointestinal tract. The effect is additive with the NSAID's own mucosal and platelet effects.
What this interaction means in plain words
Clomipramine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Sulindac belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin uptake impairs aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for GI bleeding symptoms. Use the lowest NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Sulindac?
MediHelp rates the interaction as moderate. Clomipramine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine, a potent serotonin reuptake inhibitor, can increase bleeding tendency when combined with an NSAID, particularly in the upper gastrointestinal tract. The effect is additive with the NSAID's own mucosal and platelet effects.
How serious is the interaction between Clomipramine and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for GI bleeding symptoms. Use the lowest NSAID dose for the shortest duration.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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