Drug interactions
Clomipramine + Tamsulosin
Severity: Moderate
Clomipramine and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine inhibits CYP2D6 to some degree and has alpha-blocking properties. Together with tamsulosin it may cause higher tamsulosin exposure and additive orthostatic hypotension.
What this interaction means in plain words
Clomipramine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
CYP2D6 inhibition and additive alpha-1 adrenergic blockade.
What to do
Monitor orthostatic blood pressure and counsel patients on rising slowly. Reduce the tamsulosin dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Tamsulosin?
MediHelp rates the interaction as moderate. Clomipramine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine inhibits CYP2D6 to some degree and has alpha-blocking properties. Together with tamsulosin it may cause higher tamsulosin exposure and additive orthostatic hypotension.
How serious is the interaction between Clomipramine and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and counsel patients on rising slowly. Reduce the tamsulosin dose if symptomatic.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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