Drug interactions
Clomipramine + Tolfenamic acid
Severity: Moderate
Clomipramine and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine reduces platelet serotonin uptake, which impairs platelet aggregation, and NSAIDs such as tolfenamic acid add gastric mucosal injury and antiplatelet effects. Together they raise the risk of gastrointestinal bleeding.
What this interaction means in plain words
Clomipramine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function and NSAID-induced mucosal damage.
What to do
Avoid the combination where possible, or use the lowest NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor and monitor for bleeding signs in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Clomipramine with Tolfenamic acid?
MediHelp rates the interaction as moderate. Clomipramine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine reduces platelet serotonin uptake, which impairs platelet aggregation, and NSAIDs such as tolfenamic acid add gastric mucosal injury and antiplatelet effects. Together they raise the risk of gastrointestinal bleeding.
How serious is the interaction between Clomipramine and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor and monitor for bleeding signs in higher-risk patients.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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