Drug interactions
Clonazepam + Dantrolene
Severity: Moderate
Clonazepam and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, dizziness and muscle weakness, so combined use can produce excessive drowsiness, ataxia and falls. Respiratory depression is possible in vulnerable patients.
What this interaction means in plain words
Clonazepam and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and dantrolene's central effects.
What to do
Use the lowest effective doses, counsel on driving and fall risk, and reduce the clonazepam dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Dantrolene?
MediHelp rates the interaction as moderate. Clonazepam and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, dizziness and muscle weakness, so combined use can produce excessive drowsiness, ataxia and falls. Respiratory depression is possible in vulnerable patients.
How serious is the interaction between Clonazepam and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, counsel on driving and fall risk, and reduce the clonazepam dose if oversedation occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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