Drug interactions
Clonazepam + Fenfluramine
Severity: Minor
Clonazepam and Fenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is used for seizures in Dravet and Lennox-Gastaut syndromes and is commonly given with clonazepam. Fenfluramine itself may cause somnolence, so additive sedation is possible, but no significant pharmacokinetic interaction is established.
What this interaction means in plain words
Clonazepam and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonazepam belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Possible additive CNS effects; no established pharmacokinetic mechanism.
What to do
Monitor for drowsiness when initiating or titrating fenfluramine and adjust doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Clonazepam with Fenfluramine?
MediHelp rates the interaction as minor. Clonazepam and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine is used for seizures in Dravet and Lennox-Gastaut syndromes and is commonly given with clonazepam. Fenfluramine itself may cause somnolence, so additive sedation is possible, but no significant pharmacokinetic interaction is established.
How serious is the interaction between Clonazepam and Fenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness when initiating or titrating fenfluramine and adjust doses as needed.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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