Drug interactions
Clonazepam + Idelalisib
Severity: Moderate
Clonazepam and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase clonazepam exposure, causing excessive sedation and respiratory depression. Clonazepam is partly cleared by CYP3A4, so the effect may be clinically relevant.
What this interaction means in plain words
Clonazepam and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Idelalisib strongly inhibits CYP3A4, decreasing clonazepam metabolism.
What to do
Monitor for sedation and reduce the clonazepam dose if signs of excess effect occur. Taper cautiously if idelalisib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Clonazepam with Idelalisib?
MediHelp rates the interaction as moderate. Clonazepam and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may increase clonazepam exposure, causing excessive sedation and respiratory depression. Clonazepam is partly cleared by CYP3A4, so the effect may be clinically relevant.
How serious is the interaction between Clonazepam and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduce the clonazepam dose if signs of excess effect occur. Taper cautiously if idelalisib is stopped.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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