Drug interactions
Clonazepam + Lopinavir
Severity: Moderate
Clonazepam and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, co-formulated with ritonavir, inhibits CYP3A4 and may increase clonazepam concentrations, raising the risk of oversedation and respiratory depression.
What this interaction means in plain words
Clonazepam and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated clonazepam metabolism by ritonavir-boosted lopinavir.
What to do
Start clonazepam at a lower dose and titrate cautiously while monitoring for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Clonazepam with Lopinavir?
MediHelp rates the interaction as moderate. Clonazepam and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, co-formulated with ritonavir, inhibits CYP3A4 and may increase clonazepam concentrations, raising the risk of oversedation and respiratory depression.
How serious is the interaction between Clonazepam and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start clonazepam at a lower dose and titrate cautiously while monitoring for sedation.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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