Drug interactions
Clonazepam + Mirtazapine
Severity: Moderate
Clonazepam and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can intensify drowsiness, impair psychomotor performance and cognition. Falls and accidents are a particular concern in older adults.
What this interaction means in plain words
Clonazepam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and histamine H1 antagonism.
What to do
Start with low doses and titrate gradually, giving the sedative dose at bedtime where possible. Warn patients about driving and alcohol, and review the need for both drugs periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Clonazepam with Mirtazapine?
MediHelp rates the interaction as moderate. Clonazepam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can intensify drowsiness, impair psychomotor performance and cognition. Falls and accidents are a particular concern in older adults.
How serious is the interaction between Clonazepam and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate gradually, giving the sedative dose at bedtime where possible. Warn patients about driving and alcohol, and review the need for both drugs periodically.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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