Drug interactions
Clonazepam + Modafinil
Severity: Minor
Clonazepam and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a wakefulness-promoting drug and may partly offset clonazepam sedation, but this is unreliable. Modafinil weakly induces CYP3A4, which might modestly lower clonazepam exposure.
What this interaction means in plain words
Clonazepam and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonazepam belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects, plus possible weak CYP3A4 induction by modafinil.
What to do
No routine adjustment is needed. Monitor seizure or anxiety control if clonazepam is used for those indications and the response seems reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Modafinil
Frequently asked questions
Can I take Clonazepam with Modafinil?
MediHelp rates the interaction as minor. Clonazepam and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is a wakefulness-promoting drug and may partly offset clonazepam sedation, but this is unreliable. Modafinil weakly induces CYP3A4, which might modestly lower clonazepam exposure.
How serious is the interaction between Clonazepam and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor seizure or anxiety control if clonazepam is used for those indications and the response seems reduced.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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