Drug interactions
Clonazepam + Rucaparib
Severity: Minor
Clonazepam and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib may modestly raise clonazepam concentrations and enhance sedation. The clinical effect is likely small in most patients.
What this interaction means in plain words
Clonazepam and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonazepam belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib is a weak inhibitor of CYP3A4 and may slightly reduce clonazepam metabolism.
What to do
Watch for increased drowsiness or impaired coordination after rucaparib is started. Lower the clonazepam dose only if symptoms of excess sedation appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Clonazepam with Rucaparib?
MediHelp rates the interaction as minor. Clonazepam and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib may modestly raise clonazepam concentrations and enhance sedation. The clinical effect is likely small in most patients.
How serious is the interaction between Clonazepam and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for increased drowsiness or impaired coordination after rucaparib is started. Lower the clonazepam dose only if symptoms of excess sedation appear.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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