Drug interactions
Clonazepam + Sevoflurane
Severity: Moderate
Clonazepam and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines reduce the anesthetic requirement of volatile agents and add to their CNS and respiratory depressant effects. Patients taking clonazepam may show deeper anesthesia, hypotension and slower emergence.
What this interaction means in plain words
Clonazepam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Tell the anesthetic team about clonazepam use and titrate sevoflurane to effect, monitoring end-tidal concentration and hemodynamics. Continue clonazepam perioperatively to avoid withdrawal unless advised otherwise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Clonazepam with Sevoflurane?
MediHelp rates the interaction as moderate. Clonazepam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines reduce the anesthetic requirement of volatile agents and add to their CNS and respiratory depressant effects. Patients taking clonazepam may show deeper anesthesia, hypotension and slower emergence.
How serious is the interaction between Clonazepam and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthetic team about clonazepam use and titrate sevoflurane to effect, monitoring end-tidal concentration and hemodynamics. Continue clonazepam perioperatively to avoid withdrawal unless advised otherwise.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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