Drug interactions
Clonazepam + Stiripentol
Severity: Moderate
Clonazepam and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can add to clonazepam-related sedation and somnolence. It also modulates CYP enzymes, so clonazepam exposure may change, and the combination is commonly used in refractory epilepsy.
What this interaction means in plain words
Clonazepam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus stiripentol's inhibition and induction of CYP enzymes, including CYP3A4, affecting clonazepam metabolism.
What to do
Monitor sedation and seizure control, and adjust clonazepam dose based on tolerability and response. Review the dose when stiripentol is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Clonazepam with Stiripentol?
MediHelp rates the interaction as moderate. Clonazepam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can add to clonazepam-related sedation and somnolence. It also modulates CYP enzymes, so clonazepam exposure may change, and the combination is commonly used in refractory epilepsy.
How serious is the interaction between Clonazepam and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure control, and adjust clonazepam dose based on tolerability and response. Review the dose when stiripentol is started or stopped.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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