Drug interactions
Clonazepam + Trazodone
Severity: Moderate
Clonazepam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, so combined use can intensify drowsiness, dizziness and orthostatic hypotension. Older adults are particularly vulnerable to falls and cognitive impairment.
What this interaction means in plain words
Clonazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and trazodone H1, alpha-1 and 5-HT2A antagonism.
What to do
Use the lowest effective doses and monitor for oversedation and orthostatic symptoms. Counsel patients to avoid alcohol and to take care when driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Clonazepam with Trazodone?
MediHelp rates the interaction as moderate. Clonazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, so combined use can intensify drowsiness, dizziness and orthostatic hypotension. Older adults are particularly vulnerable to falls and cognitive impairment.
How serious is the interaction between Clonazepam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and orthostatic symptoms. Counsel patients to avoid alcohol and to take care when driving.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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