Drug interactions
Clonidine + Glofitamab
Severity: Minor
Clonidine and Glofitamab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that can temporarily suppress CYP enzyme activity, potentially raising exposure to some substrates. Clonidine is cleared substantially by renal excretion, so a meaningful effect is uncertain, though cytokine release syndrome itself can cause hypotension.
What this interaction means in plain words
Clonidine and Glofitamab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Glofitamab belongs to Oncology.
Why it happens
Cytokine-mediated transient suppression of CYP activity may slightly raise clonidine exposure.
What to do
Monitor blood pressure and heart rate in the period after glofitamab doses, when cytokine release is most likely. Consider holding clonidine only if significant hypotension occurs, avoiding abrupt discontinuation where possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Clonidine with Glofitamab?
MediHelp rates the interaction as minor. Clonidine and Glofitamab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glofitamab causes cytokine release that can temporarily suppress CYP enzyme activity, potentially raising exposure to some substrates. Clonidine is cleared substantially by renal excretion, so a meaningful effect is uncertain, though cytokine release syndrome itself can cause hypotension.
How serious is the interaction between Clonidine and Glofitamab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate in the period after glofitamab doses, when cytokine release is most likely. Consider holding clonidine only if significant hypotension occurs, avoiding abrupt discontinuation where possible.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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