Drug interactions
Clonidine + Metoclopramide
Severity: Moderate
Clonidine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine causes sedation and hypotension, and metoclopramide may add drowsiness. Combined use may increase sedation and dizziness.
What this interaction means in plain words
Clonidine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression; clonidine's central alpha-2 agonism adds hypotensive effects.
What to do
Monitor blood pressure and sedation, especially when starting either drug. Adjust doses if dizziness or excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Metoclopramide?
MediHelp rates the interaction as moderate. Clonidine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine causes sedation and hypotension, and metoclopramide may add drowsiness. Combined use may increase sedation and dizziness.
How serious is the interaction between Clonidine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, especially when starting either drug. Adjust doses if dizziness or excessive drowsiness occurs.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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