Drug interactions
Clonidine + Pacritinib
Severity: Minor
Clonidine and Pacritinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib inhibits P-glycoprotein, which could increase exposure to P-gp substrates. The significance for clonidine is uncertain and probably small, though bradycardia or hypotension might be more pronounced.
What this interaction means in plain words
Clonidine and Pacritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Pacritinib belongs to Oncology.
Why it happens
Possible inhibition of P-glycoprotein efflux by pacritinib increasing clonidine absorption or reducing clearance.
What to do
Monitor heart rate and blood pressure after starting pacritinib and reduce the clonidine dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Clonidine with Pacritinib?
MediHelp rates the interaction as minor. Clonidine and Pacritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pacritinib inhibits P-glycoprotein, which could increase exposure to P-gp substrates. The significance for clonidine is uncertain and probably small, though bradycardia or hypotension might be more pronounced.
How serious is the interaction between Clonidine and Pacritinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting pacritinib and reduce the clonidine dose if bradycardia or hypotension occurs.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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