Drug interactions
Pacritinib + Posaconazole
Severity: Contraindicated
Pacritinib and Posaconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is expected to increase pacritinib exposure, increasing the risk of QT prolongation, bleeding, diarrhea and other toxicities.
What this interaction means in plain words
Pacritinib and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pacritinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole strongly inhibits CYP3A4, the main metabolic pathway of pacritinib.
What to do
Avoid the combination as labeling directs. Select an antifungal with less CYP3A4 inhibition and monitor ECG if exposure cannot be avoided.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
- Chloramphenicol + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Posaconazole?
MediHelp rates the interaction as contraindicated. Pacritinib and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole is expected to increase pacritinib exposure, increasing the risk of QT prolongation, bleeding, diarrhea and other toxicities.
How serious is the interaction between Pacritinib and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination as labeling directs. Select an antifungal with less CYP3A4 inhibition and monitor ECG if exposure cannot be avoided.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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