Drug interactions
Carbamazepine + Pacritinib
Severity: Major
Carbamazepine and Pacritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is a CYP3A4 substrate and not a clinically established inhibitor of carbamazepine metabolism. Carbamazepine, a strong CYP3A4 inducer, is expected to lower pacritinib concentrations and reduce efficacy.
What this interaction means in plain words
Carbamazepine and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Pacritinib belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4 and increases the clearance of pacritinib.
What to do
Avoid concomitant use of pacritinib with strong CYP3A4 inducers and select a non-inducing anticonvulsant. If unavoidable, monitor spleen response and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Chloramphenicol + Pacritinib Major
Frequently asked questions
Can I take Carbamazepine with Pacritinib?
MediHelp rates the interaction as major. Carbamazepine and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib is a CYP3A4 substrate and not a clinically established inhibitor of carbamazepine metabolism. Carbamazepine, a strong CYP3A4 inducer, is expected to lower pacritinib concentrations and reduce efficacy.
How serious is the interaction between Carbamazepine and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of pacritinib with strong CYP3A4 inducers and select a non-inducing anticonvulsant. If unavoidable, monitor spleen response and blood counts.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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