Drug interactions
Ketoconazole + Pacritinib
Severity: Contraindicated
Ketoconazole and Pacritinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases pacritinib exposure, which raises the risk of QT prolongation, bleeding and diarrhea. Labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Ketoconazole and Pacritinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Pacritinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces the clearance of pacritinib.
What to do
Avoid concurrent use. Select a non-CYP3A4-inhibiting antifungal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
- Chloramphenicol + Pacritinib Major
Frequently asked questions
Can I take Ketoconazole with Pacritinib?
MediHelp rates the interaction as contraindicated. Ketoconazole and Pacritinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole increases pacritinib exposure, which raises the risk of QT prolongation, bleeding and diarrhea. Labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Ketoconazole and Pacritinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Select a non-CYP3A4-inhibiting antifungal.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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