Drug interactions
Clarithromycin + Pacritinib
Severity: Contraindicated
Clarithromycin and Pacritinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin can substantially increase pacritinib exposure through CYP3A4 inhibition. This raises the risk of pacritinib toxicities such as QT prolongation, bleeding, diarrhea and cytopenias. Pacritinib labeling advises against use with strong CYP3A4 inhibitors.
What this interaction means in plain words
Clarithromycin and Pacritinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Pacritinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition decreases the metabolic clearance of pacritinib.
What to do
Avoid the combination and select a non-CYP3A4-inhibiting antibiotic such as azithromycin. If it cannot be avoided, monitor ECG and blood counts closely and consider holding pacritinib.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Pacritinib
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
- Chloramphenicol + Pacritinib Major
Frequently asked questions
Can I take Clarithromycin with Pacritinib?
MediHelp rates the interaction as contraindicated. Clarithromycin and Pacritinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin can substantially increase pacritinib exposure through CYP3A4 inhibition. This raises the risk of pacritinib toxicities such as QT prolongation, bleeding, diarrhea and cytopenias. Pacritinib labeling advises against use with strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Pacritinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-CYP3A4-inhibiting antibiotic such as azithromycin. If it cannot be avoided, monitor ECG and blood counts closely and consider holding pacritinib.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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