Drug interactions
Pacritinib + Voriconazole
Severity: Contraindicated
Pacritinib and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases pacritinib exposure through CYP3A4 inhibition. Elevated pacritinib levels may increase risks of QT prolongation, bleeding, diarrhea and other dose-related toxicities.
What this interaction means in plain words
Pacritinib and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pacritinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition decreases the metabolic clearance of pacritinib.
What to do
Avoid concomitant use of pacritinib with strong CYP3A4 inhibitors; choose a non-azole antifungal with minimal CYP3A4 inhibition where possible. If unavoidable, follow labeling and monitor ECG closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
- Chloramphenicol + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Voriconazole?
MediHelp rates the interaction as contraindicated. Pacritinib and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole increases pacritinib exposure through CYP3A4 inhibition. Elevated pacritinib levels may increase risks of QT prolongation, bleeding, diarrhea and other dose-related toxicities.
How serious is the interaction between Pacritinib and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of pacritinib with strong CYP3A4 inhibitors; choose a non-azole antifungal with minimal CYP3A4 inhibition where possible. If unavoidable, follow labeling and monitor ECG closely.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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