Drug interactions
Clonidine + Perampanel
Severity: Moderate
Clonidine and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and dizziness, and perampanel can also impair alertness and coordination. Taken together they may produce additive central nervous system depression, with a higher risk of somnolence, falls and impaired psychomotor performance.
What this interaction means in plain words
Clonidine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Perampanel belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depressant effects of central alpha-2 agonism and AMPA receptor antagonism.
What to do
Monitor for excessive sedation, dizziness and gait disturbance, especially when starting or increasing either drug. Counsel patients about driving and machinery, and reduce the dose if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Clonidine with Perampanel?
MediHelp rates the interaction as moderate. Clonidine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and dizziness, and perampanel can also impair alertness and coordination. Taken together they may produce additive central nervous system depression, with a higher risk of somnolence, falls and impaired psychomotor performance.
How serious is the interaction between Clonidine and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and gait disturbance, especially when starting or increasing either drug. Counsel patients about driving and machinery, and reduce the dose if sedation is troublesome.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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