Drug interactions
Clonidine + Vilazodone
Severity: Minor
Clonidine and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone may cause dizziness and somnolence, which can add to clonidine's sedative and blood pressure lowering effects. The interaction is generally mild.
What this interaction means in plain words
Clonidine and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Vilazodone belongs to Central Nervous System.
Why it happens
Possible additive CNS and hemodynamic effects; no established pharmacokinetic interaction.
What to do
Monitor blood pressure and sedation after initiation or dose changes. Counsel patients about dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Clonidine with Vilazodone?
MediHelp rates the interaction as minor. Clonidine and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilazodone may cause dizziness and somnolence, which can add to clonidine's sedative and blood pressure lowering effects. The interaction is generally mild.
How serious is the interaction between Clonidine and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation after initiation or dose changes. Counsel patients about dizziness.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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