Drug interactions
Clopidogrel + Dasatinib
Severity: Moderate
Clopidogrel and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib impairs platelet function and can cause thrombocytopenia and bleeding, which adds to clopidogrel's effect. Dasatinib is a time-dependent CYP3A4 inhibitor, but the bleeding risk is the more relevant concern.
What this interaction means in plain words
Clopidogrel and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Dasatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic bleeding risk from dasatinib platelet dysfunction and thrombocytopenia plus P2Y12 inhibition.
What to do
Monitor platelet counts and bleeding signs; reassess the need for dual therapy if counts fall or bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clopidogrel and Dasatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clopidogrel
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Clopidogrel with Dasatinib?
MediHelp rates the interaction as moderate. Clopidogrel and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib impairs platelet function and can cause thrombocytopenia and bleeding, which adds to clopidogrel's effect. Dasatinib is a time-dependent CYP3A4 inhibitor, but the bleeding risk is the more relevant concern.
How serious is the interaction between Clopidogrel and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and bleeding signs; reassess the need for dual therapy if counts fall or bleeding occurs.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
