Drug interactions
Clopidogrel + Dronedarone
Severity: Moderate
Clopidogrel and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may reduce conversion of clopidogrel to its active metabolite, which could weaken platelet inhibition. The clinical significance has not been clearly shown.
What this interaction means in plain words
Clopidogrel and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4, which contributes to clopidogrel bioactivation.
What to do
Monitor for thrombotic events in high-risk patients, such as after stent placement, and consider an alternative antiplatelet if concerned.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Dronedarone?
MediHelp rates the interaction as moderate. Clopidogrel and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may reduce conversion of clopidogrel to its active metabolite, which could weaken platelet inhibition. The clinical significance has not been clearly shown.
How serious is the interaction between Clopidogrel and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for thrombotic events in high-risk patients, such as after stent placement, and consider an alternative antiplatelet if concerned.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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