Drug interactions
Clopidogrel + Edoxaban
Severity: Moderate
Clopidogrel and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding clopidogrel to edoxaban increases the likelihood of clinically significant bleeding compared with edoxaban alone. The combination is sometimes needed, for example in atrial fibrillation after stenting, but the bleeding burden is higher.
What this interaction means in plain words
Clopidogrel and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Why it happens
Additive effects of P2Y12-mediated platelet inhibition and factor Xa inhibition on haemostasis.
What to do
Use only when there is a clear indication, keep the combined therapy to the shortest necessary duration, and consider gastroprotection with a proton pump inhibitor. Monitor haemoglobin and for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Edoxaban?
MediHelp rates the interaction as moderate. Clopidogrel and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding clopidogrel to edoxaban increases the likelihood of clinically significant bleeding compared with edoxaban alone. The combination is sometimes needed, for example in atrial fibrillation after stenting, but the bleeding burden is higher.
How serious is the interaction between Clopidogrel and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when there is a clear indication, keep the combined therapy to the shortest necessary duration, and consider gastroprotection with a proton pump inhibitor. Monitor haemoglobin and for signs of bleeding.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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