Drug interactions
Clopidogrel + Eslicarbazepine
Severity: Moderate
Clopidogrel and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine inhibits CYP2C19, which is needed to activate clopidogrel, so platelet inhibition may be reduced. This could lessen protection against stent thrombosis or ischemic events.
What this interaction means in plain words
Clopidogrel and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 reduces formation of clopidogrel's active metabolite.
What to do
Avoid the combination in high thrombotic risk patients where possible, using another antiepileptic. If it is necessary, consider platelet function testing or an alternative antiplatelet such as prasugrel or ticagrelor where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Clopidogrel with Eslicarbazepine?
MediHelp rates the interaction as moderate. Clopidogrel and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine inhibits CYP2C19, which is needed to activate clopidogrel, so platelet inhibition may be reduced. This could lessen protection against stent thrombosis or ischemic events.
How serious is the interaction between Clopidogrel and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in high thrombotic risk patients where possible, using another antiepileptic. If it is necessary, consider platelet function testing or an alternative antiplatelet such as prasugrel or ticagrelor where appropriate.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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