Drug interactions
Clopidogrel + Etravirine
Severity: Moderate
Clopidogrel and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C19, which participates in clopidogrel activation, so antiplatelet effect may be diminished. This may raise the risk of thrombotic events in high-risk patients.
What this interaction means in plain words
Clopidogrel and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Etravirine belongs to Anti Virals.
Why it happens
CYP2C19 inhibition by etravirine reduces formation of clopidogrel's active metabolite.
What to do
Consider an alternative antiplatelet not dependent on CYP2C19, such as prasugrel or ticagrelor, if clinically appropriate. Otherwise monitor for ischemic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clopidogrel and Etravirine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clopidogrel
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Clopidogrel with Etravirine?
MediHelp rates the interaction as moderate. Clopidogrel and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine inhibits CYP2C19, which participates in clopidogrel activation, so antiplatelet effect may be diminished. This may raise the risk of thrombotic events in high-risk patients.
How serious is the interaction between Clopidogrel and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiplatelet not dependent on CYP2C19, such as prasugrel or ticagrelor, if clinically appropriate. Otherwise monitor for ischemic events.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
