Drug interactions
Clopidogrel + Voriconazole
Severity: Moderate
Clopidogrel and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may reduce activation of clopidogrel to its active metabolite, potentially weakening platelet inhibition and raising thrombotic risk.
What this interaction means in plain words
Clopidogrel and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C19, which is needed to form the active clopidogrel metabolite.
What to do
Consider an alternative antifungal or an antiplatelet not dependent on CYP2C19, such as prasugrel or ticagrelor where appropriate. Monitor for ischemic events if the combination continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Voriconazole?
MediHelp rates the interaction as moderate. Clopidogrel and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may reduce activation of clopidogrel to its active metabolite, potentially weakening platelet inhibition and raising thrombotic risk.
How serious is the interaction between Clopidogrel and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antifungal or an antiplatelet not dependent on CYP2C19, such as prasugrel or ticagrelor where appropriate. Monitor for ischemic events if the combination continues.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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