Drug interactions
Clorazepate + Cyclizine
Severity: Moderate
Clorazepate and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine and its effects add to those of clorazepate. The patient may experience increased drowsiness, slowed reaction times and impaired concentration.
What this interaction means in plain words
Clorazepate and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-A potentiation and central H1-receptor antagonism.
What to do
Warn patients about increased drowsiness and advise against driving or operating machinery until the response is known. Reduce doses if excessive sedation occurs, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Clorazepate with Cyclizine?
MediHelp rates the interaction as moderate. Clorazepate and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine and its effects add to those of clorazepate. The patient may experience increased drowsiness, slowed reaction times and impaired concentration.
How serious is the interaction between Clorazepate and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about increased drowsiness and advise against driving or operating machinery until the response is known. Reduce doses if excessive sedation occurs, especially in older adults.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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