Drug interactions
Clorazepate + Desipramine
Severity: Moderate
Clorazepate and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases central nervous system depression, causing drowsiness and psychomotor impairment. Desipramine is less sedating than many tricyclics, but the combination can still impair alertness and increase fall risk.
What this interaction means in plain words
Clorazepate and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and tricyclic antihistaminic and anticholinergic effects.
What to do
Monitor for excessive sedation and falls, particularly in older patients, and use the lowest effective doses. Advise caution with driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clorazepate with Desipramine?
MediHelp rates the interaction as moderate. Clorazepate and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use increases central nervous system depression, causing drowsiness and psychomotor impairment. Desipramine is less sedating than many tricyclics, but the combination can still impair alertness and increase fall risk.
How serious is the interaction between Clorazepate and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and falls, particularly in older patients, and use the lowest effective doses. Advise caution with driving and alcohol.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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