Drug interactions
Clorazepate + Lenacapavir
Severity: Moderate
Clorazepate and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor that may raise exposure to the active metabolite of clorazepate, causing prolonged sedation and psychomotor impairment. The inhibitory effect may persist for months after the last subcutaneous dose.
What this interaction means in plain words
Clorazepate and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of nordiazepam by lenacapavir.
What to do
Monitor for oversedation and consider reducing the clorazepate dose during and after lenacapavir therapy. Counsel patients on impairment of alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Clorazepate with Lenacapavir?
MediHelp rates the interaction as moderate. Clorazepate and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor that may raise exposure to the active metabolite of clorazepate, causing prolonged sedation and psychomotor impairment. The inhibitory effect may persist for months after the last subcutaneous dose.
How serious is the interaction between Clorazepate and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider reducing the clorazepate dose during and after lenacapavir therapy. Counsel patients on impairment of alertness.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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